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Multidisciplinary research shows impact of Litesse Fibre on gut microbiota & lipid metabolism in Mice
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Wednesday, 17 March, 2021, 08 : 00 AM [IST]
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NewYork, USA
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Continuing their leading research in the field of nutrition and health, IFF (formerly DuPont Nutrition and Biosciences) researchers, in collaboration with researchers from Afekta Technologies Limited, Finland, and the University of Oulu, Finland, recently released the findings of their latest study on the health effects of Litessepolydextrose, a soluble fibre with prebiotic properties.
As reported previously (Raza et al. 2017), Litesse was found to alter the gut microbiota, and to reduce fasting triglycerides and total cholesterol plasma levels in mice being fed a Western diet - a diet characterised by a high intake of saturated fats and sucrose, and a low intake of fibre. This new study builds upon existing research, to help further understand the mechanisms of action that Litesse has at the molecular level.
Markku Saarinen, senior scientist, IFF, said, ‘‘The previous findings were so interesting that we wanted to explore in more detail what is behind these positive changes in metabolism and microbiota. Thus, we extended the focus of the previous research to a molecular level.
The study examined blood and tissue samples from the mice fed a Western diet, with or without oral administration of Litessepolydextrose. Metabolomic analyses of these tissue samples were conducted and revealed significant differences between mice fed with polydextrose and the mice in the control group.
Dr Olli Kärkkäinen, CEO, Afekta Technologies Limited, said, “Metabolomic analytics are increasingly being used in food and nutrition research and, when investigating research questions related to the function of gut microbiota. With metabolomics, it is possible to explore the conversion products made by gut microbiota from dietary components, and examine what kind of metabolic alterations they evoke in the circulation and potential target tissues.”
The results showed that Litessepolydextrose caused differential metabolite patterns in blood and adipose tissues. It also demonstrated that one-carbon metabolism, bile acid and tryptophan metabolism were associated with the hypolipidemic effects observed in the mice receiving polydextrose. The inclusion of polydextrose in the diet may have also altered the absorption of other dietary components, resulting in the hypolipidemic effect.
Dr Heli Anglenius, senior scientist, IFF, said, “While there are many dietary fibres on the market today, not all fibres act in the same way. Our study strongly supports this, which is why further investigation on whether the positive changes in lipid metabolism are also observed in humans is warranted.”
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